# Ovarian Cancer

Mebendazole has strong mechanistic interest in **ovarian cancer**, especially because it appears to affect metastasis, apoptosis, and key survival pathways.

### Overview

The ovarian-cancer literature focuses on tubulin disruption, apoptosis, invasion, and suppression of Akt, NF-κB, and β-catenin-related signalling.

### Key findings

* Mebendazole inhibits tubulin polymerisation and disrupts cell division
* Promotes apoptosis in ovarian cancer cell lines
* Suppresses Akt, NF-κB, and β-catenin pathways
* Reduces metastatic and invasive behaviour in preclinical models

### Clinical positioning

This remains a preclinical area, but one with strong pathway relevance and real interest for future repurposing work.

### References

Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC11763501/>

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