# Lung Cancer

Mebendazole has meaningful mechanistic relevance in **lung cancer**, especially in tumours driven by ERK / MAPK and survival-pathway signalling.

### Overview

The current note set here is more mechanism-driven than trial-driven, but lung cancer remains an important fit for mebendazole because of ERK, angiogenesis, and resistance-related biology.

### Key findings

* ERK / MAPK signalling is frequently upregulated in NSCLC
* Mebendazole's pathway effects suggest relevance in proliferation, spread, and resistance contexts
* Combination strategies are likely to matter more than monotherapy in high-ERK disease

### Clinical positioning

This remains an emerging fit rather than a fully developed clinical one, but it is a reasonable page to keep in the structure.

### References

Mebendazole as a Candidate for Drug Repurposing in Oncology\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC6769799/>

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