# Breast Cancer

Mebendazole has important mechanistic relevance in **breast cancer**, especially around hypoxia, HIF signalling, and aggressive or stem-like tumour behaviour.

### Overview

The breast-cancer evidence centres on HIF inhibition, AKT and STAT3-related biology, and reduced stem-like features, especially in triple-negative contexts.

### Key findings

* Mebendazole disrupts HIF transcriptional activity in breast cancer cells
* Suppresses BCL-2, AKT, and STAT3-linked survival signalling
* May reduce stem-like properties in triple-negative models
* Broad ERK/MAPK-related significance is also relevant in aggressive subtypes

### Clinical positioning

This is still preclinical, but the HIF and hypoxia angle makes it especially interesting in aggressive breast-cancer biology.

### References

Mebendazole Treatment Disrupts the Transcriptional Activity of HIFs in Breast Cancer\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC9954103/>

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This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use.
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