# Brain Tumours

Brain tumours are one of the strongest translational areas for mebendazole because the literature includes meaningful preclinical CNS work and clinical repurposing interest.

### Overview

The strongest evidence here is in medulloblastoma and broader CNS tumour models, where mebendazole combines anti-angiogenic, anti-mitotic, and survival-prolonging effects.

### Key findings

* Mebendazole was effective across diverse medulloblastoma models
* It selectively inhibited VEGFR2-driven angiogenesis in brain tumour models
* Survival extension was reported with minimal effect on normal brain vasculature
* Broader CNS tumour repurposing reviews support ongoing clinical interest

### Clinical positioning

This is one of the most important pages in the topic because CNS-tumour repurposing is one of the clearest current niches for mebendazole.

### References

Effective treatment of diverse medulloblastoma models with mebendazole\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC4483072/>

Repurposing the anthelmintic drug mebendazole in CNS tumour research\
<https://academic.oup.com/noa/article/7/1/vdaf066/8097633>

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