# Pharmacokinetics & Dosing
Itraconazole dosing in oncology is distinct from routine antifungal use because repurposing studies often use higher or protocol-specific schedules.
### Dosing patterns seen in studies
* **continuous daily dosing:** often 200–600 mg daily
* **cycled dosing:** 400 mg daily for 4 days, repeated every 2 weeks in some retrospective combination settings
### Why dosing matters
The repurposing question is not just whether itraconazole can be used. It is whether it can be used at doses that meaningfully affect tumour biology while remaining tolerable.
### Practical interpretation
Published studies suggest both continuous and cyclical strategies have been explored. The right approach depends on cancer type, co-treatments, and the clinician's rationale for use.
### Key References
A phase II trial in metastatic castration-resistant prostate cancer using itraconazole\
Repurposing itraconazole for the treatment of cancer\
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