# Aspirin Evidence by Cancer Type
This section brings together the aspirin evidence across major cancer types.
The pages do not all say the same thing.
That is the point of the section.
Some cancers have:
* strong **prevention** signals
* stronger **post-diagnosis** or **anti-metastatic** logic
* specific **biomarker-defined** subgroups
* important **negative** or **mixed** findings that change the interpretation
That is why each cancer has its own page.
### How to use this section
Use these pages to answer three practical questions:
1. **Is there a real human signal in this cancer type?**
2. **If so, is it prevention, recurrence, survival, or metastasis that looks most relevant?**
3. **Is the signal broad, or does it depend on dose, duration, subtype, or biomarker status?**
Taken together, this section now covers:
* **Phase 3** biomarker-selected data in colorectal cancer
* strong **prevention** signals in liver, pancreatic, and endometrial cancer
* **post-surgical recurrence** data in prostate cancer
* **immunotherapy-combination** logic in melanoma
* **stem-cell**, **chemoresistance**, and **delivery-barrier** biology in glioblastoma
* strong **metastasis** and **cisplatin-sensitisation** data in osteosarcoma
* a distinct **MPN** page in myelofibrosis, where aspirin is already clinically relevant for thrombosis but still unproven for disease modification
* a balanced **mixed-evidence** holding page for additional tumour types
### Full cancer pages
* [Colorectal Cancer](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/colorectal-cancer.md) — strongest overall aspirin page, with **PIK3CA-selected Phase 3** evidence
* [Breast Cancer](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/breast-cancer.md) — mixed but important, including the negative **Phase 3** trial and subgroup logic
* [Gastric Cancer](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/gastric-cancer.md) — strongest in **H. pylori-linked**, non-cardia, intestinal-type disease
* [Liver Cancer (Hepatocellular Carcinoma)](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/liver-cancer-hepatocellular-carcinoma.md) — one of the strongest **prevention** pages, especially in chronic liver disease
* [Lung Cancer](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/lung-cancer.md) — long-term prevention plus strong **TXA2** and metastasis biology
* [Pancreatic Cancer](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/pancreatic-cancer.md) — one of the biggest prevention-effect pages.
* [Melanoma](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/melanoma.md) — important **immunotherapy-combination** page with a critical high-dose toxicity lesson
* [Glioblastoma](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/glioblastoma.md) — strong preclinical page covering **GSCs**, **TMZ resistance**, and the **BBB** problem
* [Osteosarcoma](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/osteosarcoma.md) — lung-metastasis suppression and **cisplatin sensitisation**
* [Prostate Cancer](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/prostate-cancer.md) — prevention, post-diagnosis survival, post-surgical recurrence, and biomarker-defined subgroups
* [Endometrial Cancer](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/endometrial-cancer.md) — one of the stronger gynaecological aspirin pages, especially in obesity-linked disease
* [Ovarian Cancer](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/ovarian-cancer.md) — real but more modest prevention signal, with histotype-specific differences
* [Myelofibrosis](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/myelofibrosis.md) — distinct from the solid-tumour pages because aspirin is already used in selected patients for thrombosis, while anti-fibrotic benefit remains unproven
### Shorter summaries and mixed-signal areas
* [Other Cancer Types](/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type/other-cancer-types.md) — short evidence summaries for **bladder cancer**, **lymphoma subtypes**, **cervical cancer**, and key cautions on cancers that should stay out for now
### What this section shows overall
Aspirin is not one simple oncology story.
It looks strongest when one or more of these are true:
* **platelet biology** and metastatic spread matter
* **COX-2 / PGE2** signalling is central to tumour immune evasion
* the cancer develops through a long **inflammatory pre-cancer window**
* there is a specific **molecular subgroup** that appears aspirin-sensitive
That is why this section has become one of the most useful ways to judge where aspirin is genuinely promising, where it is still experimental, and where it should be approached with real caution.
Would you like to ask Abbey about the information shared on this page? Would you like to contribute your experience, research or ideas to this page? Perhaps you want to point out something that needs changing?
Feedback Form
{% hint style="warning" %}
This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use.
{% endhint %}
{% hint style="info" %}
© 2026 Abbey Mitchell. All rights reserved. Please share by URL rather than copying page text.
{% endhint %}
---
# Agent Instructions: Querying This Documentation
If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.
Perform an HTTP GET request on the current page URL with the `ask` query parameter:
```
GET https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/off-label-drugs-for-cancer/aspirin-in-oncology/aspirin-evidence-by-cancer-type.md?ask=
```
The question should be specific, self-contained, and written in natural language.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.
Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.