> For the complete documentation index, see [llms.txt](https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/wfa-evidence-by-cancer-type/other-cancer-types.md). # Other Cancer Types WFA has preclinical evidence across several additional cancer types. These settings do not yet support the same level of confidence as breast or ovarian cancer, but they are not trivial. ### Overview | Cancer type | Key signal | Evidence level | | --------------- | ------------------------------------------------------------------- | ------------------------------ | | Colorectal | `HSP90`, `HIF-1α`, and EMT axis inhibition | Cell line and animal | | Osteosarcoma | Published Phase I oncology trial and pro-apoptotic preclinical work | Phase I human plus preclinical | | Prostate | G2/M arrest and proteomic target mapping | Cell line established | | Pancreatic | Oxaliplatin synergy and CSC-related signalling | Cell line only | | Cervical | HPV `E6/E7` downregulation and xenograft activity | Cell line and animal | | B-cell lymphoma | `NF-κB`, BCR signalling, and HSP90 disruption | Cell line and animal | | Hepatocellular | Ferroptosis and resistance relevance via `Keap1/Nrf2` | Cell line and animal | | Thyroid | Sorafenib synergy | Cell line and animal | ### Key references Bolleddula J. et al. — Phase I osteosarcoma trial of withaferin A.\ Sun S. et al. — colorectal cancer growth and metastasis work targeting `HIF-1α` and EMT.\ Sarin N. et al. — pancreatic cancer chemoresistance and oxaliplatin synergy.\ Gopalakrishnan R. et al. — anti-cancer activity of withaferin A in B-cell lymphoma.\ Guo J. et al. — hepatocellular-cancer and ferroptosis-relevant review context.\ ### What this means in practice These settings expand the plausibility of WFA as a broad anticancer platform. They do not carry the same translational weight. Osteosarcoma is the main exception because it has direct human Phase I relevance, even though efficacy remains unproven. The others remain exploratory disease areas where mechanism is ahead of clinical translation. ### Bottom line These thinner signals matter most as evidence of breadth, not as proof of near-term clinical readiness. Access and availability:\ Source: MCS Formulas, “Withaferin A Pro Liposomal.”\ `50 mg` WFA per capsule. Available via healthcare professional request.\ ### In this section #### Core pages * [Withaferin A (WFA) in Oncology](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology.md) * [Evidence Summary](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/evidence-summary.md) * [Anticancer Mechanisms](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/anti-cancer-mechanisms.md) * [Immune Effects](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/immune-effects.md) * [Synergistic Combinations](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/synergistic-combinations.md) #### Cancer-type pages * [WFA Evidence by Cancer Type](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/wfa-evidence-by-cancer-type.md) * [Breast Cancer](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/wfa-evidence-by-cancer-type/breast-cancer.md) * [Ovarian Cancer](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/wfa-evidence-by-cancer-type/ovarian-cancer.md) * [Non-Small Cell Lung Cancer](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/wfa-evidence-by-cancer-type/non-small-cell-lung-cancer.md) * [Glioblastoma](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/wfa-evidence-by-cancer-type/glioblastoma.md) * [Other Cancer Types](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/wfa-evidence-by-cancer-type/other-cancer-types.md) #### Practical pages * [Pharmacokinetics & Metabolism](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/pharmacokinetics-and-metabolism.md) * [Sourcing Quality](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/sourcing-quality.md) * [Safety, Interactions and WFA Dosing](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/safety-interactions-and-wfa-dosing.md) * [Hormones — ER-α and Androgens](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/hormones-er-a-and-androgens.md) * [Terrain Support — Liposomal WFA vs Whole-Plant Ashwagandha](/myhealingcommunity-docs/natural-medicines/withaferin-a-wfa-in-oncology/terrain-support-liposomal-wfa-vs-whole-plant-ashwagandha.md) {% hint style="warning" %} This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use. {% endhint %} {% hint style="info" %} © 2026 Abbey Mitchell. All rights reserved. Please share by URL rather than copying page text. {% endhint %} --- # Agent Instructions This documentation is published with GitBook. GitBook is the documentation platform designed so that both humans and AI agents can read, navigate, and reason over technical content effectively. Learn more at gitbook.com. ## Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. 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