# Urolithin A Evidence by Cancer Type

This section groups the Urolithin A oncology evidence into focused cancer-type pages as the evidence base becomes strong enough to support them properly.

That structure keeps each cancer page easier to navigate and makes future updates simpler.

### Available pages

* [**Colorectal Cancer**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/colorectal-cancer.md) — strongest current evidence, including Wnt signalling, AKT1-related immune effects, and chemotherapy sensitisation
* [**Pancreatic Cancer**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/pancreatic-cancer.md) — one of the strongest mechanistic settings, with KRAS-pathway relevance, stromal remodelling, and anti-PD-1 sensitisation data
* [**Prostate Cancer**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/prostate-cancer.md) — most clinically advanced evidence, including androgen-receptor signalling, NK-cell data, and the active phase II trial
* [**Breast Cancer**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/breast-cancer.md) — subtype-based evidence across ER-positive, triple-negative, and HER2-positive contexts
* [**Endometrial Cancer**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/endometrial-cancer.md) — ERα and ERβ remodelling, G2/M arrest, and one of the cleaner hormone-biology settings for Urolithin A
* [**Glioblastoma**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/glioblastoma.md) — blood-brain-barrier penetration, Sirt1-FOXO1 signalling, and tumour-microenvironment findings
* [**Liver Cancer (HCC)**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/liver-cancer-hcc.md) — direct HCC cell-line findings plus wider hepatoprotective and gut-liver-axis relevance in chronic liver disease
* [**Lung Cancer**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/lung-cancer.md) — multiple independent NSCLC mechanisms, including EMT inhibition, autophagy-linked mTOR suppression, and in vivo xenograft evidence
* [**Osteosarcoma**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/osteosarcoma.md) — early anti-metastatic evidence focused on migration, invasion, and MMP2/MMP9 suppression
* [**Bladder Cancer**](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type/bladder-cancer.md) — unusually strong UMUC3 sensitivity, G2/M arrest, apoptosis, and plausible urinary-exposure relevance

If a cancer type is not listed here yet, it can be added later as the evidence base grows.

### In this section

* [Overview](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology.md)
* [Evidence Summary](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/evidence-summary.md)
* [Anticancer Mechanisms](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/anticancer-mechanisms.md)
* [Immune Effects](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/immune-effects.md)
* [Synergistic Combinations](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/synergistic-combinations.md)
* [Urolithin A Evidence by Cancer Type](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type.md)
* [Pharmacokinetics & Metabolism](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/pharmacokinetics-and-metabolism.md)
* [Safety & Interactions](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/safety-and-interactions.md)
* [Dosing & Timing](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/dosing-and-timing.md)
* [Sourcing Quality Urolithin A](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/sourcing-quality-urolithin-a.md)
* [Sensitisation to Conventional Therapies](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/sensitisation-to-conventional-therapies.md)
* [Antimicrobial, Antiviral & Terrain Support](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/antimicrobial-antiviral-and-terrain-support.md)

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### Key References

Urolithin A research overview and oncology applications\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC12188533/>

Urolithin A in pancreatic cancer models and combination research\
<https://aacrjournals.org/mct/article/18/2/301/168585/Urolithin-A-a-Novel-Natural-Compound-to-Target>

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