# Dosing & Timing ### What human studies have used Published human studies most often use: * **250 mg/day** * **500 mg/day** * **1000 mg/day** These doses have mainly been studied in healthy or non-oncology populations, with some early oncology-specific interest now emerging. ### Why 1000 mg/day comes up most often The highest commonly cited human dose in the current literature is 1000 mg/day. That is also the dose range showing up in some oncology-relevant clinical-trial settings. That does not make it an established cancer dose. It simply reflects where the research is now concentrating. ### Timing considerations No oncology-specific timing protocol has been established. The practical points currently seem to be: * daily consistency likely matters more than exact clock timing * food timing appears flexible in the human data so far * active-treatment timing still needs clinician review ### Why diet is not enough for dosing logic Dietary intake of ellagitannin-rich foods is not a reliable way to produce predictable Urolithin A exposure. That is because microbiome conversion varies so much between individuals. If the goal is consistent exposure, direct supplementation makes more sense than relying on pomegranate or other precursor foods alone. ### What is still not known Several dosing questions remain open: * effective oncology-specific dose ranges * best dosing alongside chemotherapy, endocrine therapy, targeted therapy, or immunotherapy * whether higher oral dosing produces meaningfully better tumour-site effects * whether different cancer settings need different dosing logic ### Bottom line Urolithin A has a usable human dosing range in the literature. It does not yet have a settled oncology dosing protocol. That is why it should still be treated as investigational in cancer care. ### In this section * [Overview](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology.md) * [Evidence Summary](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/evidence-summary.md) * [Anticancer Mechanisms](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/anticancer-mechanisms.md) * [Immune Effects](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/immune-effects.md) * [Synergistic Combinations](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/synergistic-combinations.md) * [Urolithin A Evidence by Cancer Type](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/urolithin-a-evidence-by-cancer-type.md) * [Pharmacokinetics & Metabolism](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/pharmacokinetics-and-metabolism.md) * [Safety & Interactions](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/safety-and-interactions.md) * [Dosing & Timing](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/dosing-and-timing.md) * [Sourcing Quality Urolithin A](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/sourcing-quality-urolithin-a.md) * [Sensitisation to Conventional Therapies](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/sensitisation-to-conventional-therapies.md) * [Antimicrobial, Antiviral & Terrain Support](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/antimicrobial-antiviral-and-terrain-support.md) ### Key References Human safety, absorption, and plasma exposure of oral Urolithin A\ Direct supplementation compared with dietary precursor exposure\ Urolithin A prostate-trial listing\ {% hint style="warning" %} This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use. {% endhint %} {% hint style="info" %} © 2026 Abbey Mitchell. All rights reserved. Please share by URL rather than copying page text. {% endhint %} --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/dosing-and-timing.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.