# Osteosarcoma

Polydatin has meaningful preclinical activity in osteosarcoma, including radiosensitisation and reversal of doxorubicin resistance.

### Overview

The osteosarcoma literature highlights cell-cycle effects, apoptosis induction, and treatment-resistance modulation.

### Key findings

* Promotes S-phase cell-cycle arrest in osteosarcoma cells
* Shows radiosensitising effects when combined with radiation
* Overcomes doxorubicin resistance through TUG1/Akt-related signalling changes
* Increases Bax/Bcl2 ratio and suppresses β-catenin-related survival pathways
* Reduces viability, migration, and proliferation in U2OS and MG63 models

### Practical interpretation

Osteosarcoma is a good example of polydatin acting as both a growth inhibitor and a resistance-modulating adjunct.

### References

Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC9656535/>

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