# Lung Cancer

Polydatin has strong preclinical relevance in lung cancer, especially in non-small-cell lung cancer models.

### Overview

The lung cancer literature centres on apoptosis, S-phase arrest, and synergy with cisplatin.

### Key findings

* Inhibits proliferation of A549 and NCI-H1975 lung cancer cells in a dose-dependent manner
* Causes apoptosis and S-phase cell-cycle arrest
* Increases Bax and decreases Bcl-2
* Suppresses cyclin D1 expression
* Acts as a potential NOX5 agonist in NSCLC, enhancing cisplatin antitumour activity

### Practical interpretation

The lung cancer evidence is still preclinical, but consistently supports polydatin as a redox-active and apoptosis-promoting adjunct.

### References

Polydatin inhibits growth of lung cancer cells by inducing apoptosis and cell cycle arrest\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC3861602/>

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