# Liver Cancer (HCC)

Polydatin is especially interesting in hepatocellular carcinoma because it combines direct anticancer effects with evidence of lower toxicity in normal liver cells.

### Overview

The HCC literature suggests selective toxicity toward tumour cells, apoptosis induction, and treatment-sensitising relevance.

### Key findings

* Selectively inhibits proliferation of multiple HCC cell lines while sparing normal liver cells in comparative work
* Induces dose-dependent apoptosis with Bax/Bcl-2 shifts and caspase activation
* Inhibits proliferation, invasion, and migration
* Blocks AKT/STAT3-FOXO1 signalling in HCC models
* Sensitises liver cancer cells to doxorubicin and cisplatin

### Practical interpretation

HCC is one of the more attractive biological settings for polydatin because tumour selectivity and liver-related context both matter clinically.

### References

Polydatin Inhibits Hepatocellular Carcinoma Cell Proliferation and Sensitizes Doxorubicin and Cisplatin\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC9856937/>

Polydatin inhibits cell proliferation, invasion and migration, and induces apoptosis in hepatocellular carcinoma cell\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC5856444/>

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