# Blood Cancers Polydatin has relevant preclinical evidence in several blood cancers, including acute myeloid leukaemia and acute lymphoblastic leukaemia. ### Overview The blood-cancer literature focuses on apoptosis, autophagy, cell-cycle effects, and growth suppression. ### Acute myeloid leukaemia * Polydatin inhibits AML tumour growth in vivo in animal work * Induces cell death through autophagy-related pathways * Targets survival signalling relevant to leukaemia cell persistence ### Acute lymphoblastic leukaemia * Shows dose-dependent and time-dependent antiproliferative effects in MOLT-4 cells * Cell-cycle arrest and apoptosis may be potentiated when combined with resveratrol * Pediatric leukaemia models also show cytotoxic activity ### Practical interpretation This is still preclinical territory, but blood cancers remain one of the meaningful mechanistic areas in the polydatin literature. ### References Polydatin-induced cell apoptosis and cell cycle arrest are potentiated by pyridaben in MOLT-4 leukemia cells\ Targeting autophagy: polydatin's role in inducing cell death in AML\ {% hint style="warning" %} This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use. {% endhint %} {% hint style="info" %} © 2026 Abbey Mitchell. All rights reserved. Please share by URL rather than copying page text. {% endhint %} --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/natural-medicines/polydatin-in-oncology/polydatin-evidence-by-cancer-type/blood-cancers.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.