# Immune Effects

### **An emerging frontier: G6PD inhibition and immunotherapy**

A 2024 study published in the Journal for ImmunoTherapy of Cancer added a further dimension to this landscape.

G6PD blockade was found to trigger immunogenic cell death in tumours — a form of cancer cell death that activates the immune system against the tumour — and significantly amplified the efficacy of checkpoint inhibitor immunotherapy (PD-1/PD-L1 inhibitors) in preclinical models.

This study positions G6PD inhibition not only as a direct anti-tumour and chemosensitisation strategy but potentially as an immunotherapy enhancer — a combination space of considerable current interest in oncology research.

Whether polydatin could serve this role alongside immunotherapy in humans has not yet been tested in clinical trials.

**Blockade of glucose-6-phosphate dehydrogenase induces immunogenic cell death and amplifies immunotherapy response (Journal for ImmunoTherapy of Cancer, 2024)**\
<https://jitc.bmj.com/content/12/7/e008441>

**See also:** [G6PD Inhibition](/myhealingcommunity-docs/natural-medicines/polydatin-in-oncology/anticancer-mechanisms/g6pd-inhibition.md)

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