# NRF2 Impact

In normal cells, polydatin activates the Nrf2/HO-1/NQO1 antioxidant pathway, providing cytoprotection.

In cancer cells, the effect is more complex and may depend on baseline Nrf2 status, dose, and duration of exposure. This pathway contributes to the compound's favourable safety profile.

\ <mark style="color:blue;">See</mark> <mark style="color:blue;">**References for Mechanisms of Action**</mark> <mark style="color:blue;">Page</mark>

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