# Prostate Cancer

EGCG is the main green tea catechin, and prostate cancer is one of the most clinically advanced areas of EGCG research.

### Overview

This literature includes prevention trials, biomarker-focused human work, and extensive pathway data tied to androgen signalling, IGF-1, and inflammation.

### Key human data

* A randomised trial in men with high-grade prostatic intraepithelial neoplasia showed a strong reduction in progression to prostate cancer with green tea catechins
* Presurgical biomarker studies showed tissue-level changes in growth and invasion markers after Polyphenon E use
* Early work in castration-resistant disease showed tolerability and limited stabilisation signals

### Key preclinical data

* EGCG suppresses androgen receptor signalling
* Reduces IGF-1, IGF-1R, COX-2, and iNOS-related pathways
* Inhibits PI3K/Akt/mTOR in androgen-sensitive and resistant models

### Clinical positioning

Prostate cancer is one of the stronger EGCG settings, especially for early disease, chemoprevention, and recurrence-focused support.

### References

Epigallocatechin-3-gallate (EGCG) prevents progression of prostate cancer in high-grade prostatic intraepithelial neoplasia\
<https://pubmed.ncbi.nlm.nih.gov/16331380/>

Polyphenon E in men with localized prostate cancer: a presurgical biomarker trial\
<https://pubmed.ncbi.nlm.nih.gov/22328437/>

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This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use.
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