# Blood Cancers

EGCG is the most studied green tea catechin in haematologic malignancies, especially chronic lymphocytic leukaemia.

### Overview

This is one of the few areas where EGCG has meaningful human trial data beyond prevention-only settings.

### Key human data

* Mayo Clinic Phase II work in early-stage CLL showed sustained reductions in lymphocyte counts and lymph node size in subsets of patients
* Follow-up work supported the reproducibility of the biologic signal in CLL

### Key preclinical data

* EGCG induces apoptosis in CLL cells through Mcl-1 downregulation and caspase activation
* In leukaemia models, EGCG has shown immune-supportive and tumour-burden effects
* STAT3 suppression is relevant in several blood-cancer models

### Major caution

**Avoid combining EGCG with bortezomib (Velcade).** This is one of the most important practical cautions in the whole EGCG topic because the interaction may reduce bortezomib efficacy.

### Clinical positioning

CLL is the strongest clinical niche for EGCG in blood cancers, especially in watch-and-wait or early supportive contexts.

### References

Phase II Trial of Daily, Oral Polyphenon E in Patients With Asymptomatic Rai Stage 0 to II Chronic Lymphocytic Leukemia\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC4876335/>

Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications\
<https://pmc.ncbi.nlm.nih.gov/articles/PMC10343677/>

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