# Dosing & Timing EGCG is the main catechin in **green tea**, but dosing only makes sense when bioavailability and treatment context are taken into account. ### Core issue Most in vitro studies use concentrations that are hard to reproduce systemically with standard oral dosing. That means practical dosing discussions need to separate: * prevention-oriented use * adjunctive treatment support * concentrated extract use * beverage intake versus supplemental intake ### Research dose ranges Common supplemental study ranges often fall in the **200–800 mg/day** range, with higher-dose concentrated extract use requiring more caution. ### Timing considerations * Empty-stomach use may improve absorption but may also increase liver risk with concentrated extracts * Divided dosing may make sense because of the short half-life * Some integrative clinicians prefer to pause EGCG around radiotherapy or oxidative chemotherapy days, then resume between cycles * Timing should be individualised with the treatment team ### Practical takeaway There is no one universal EGCG dose for cancer. The key questions are: * what form is being used? * is the goal prevention, support, or active-treatment adjunctive use? * what drugs are being taken alongside it? * is the dose high enough to create liver or interaction concerns? ### Key References Anticancer Molecular Mechanisms of Epigallocatechin-3-Gallate (EGCG)\ Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications\ {% hint style="warning" %} This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use. {% endhint %} {% hint style="info" %} © 2026 Abbey Mitchell. All rights reserved. Please share by URL rather than copying page text. {% endhint %} --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/natural-medicines/egcg-in-oncology/dosing-and-timing.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.