> For the complete documentation index, see [llms.txt](https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/natural-medicines/apigenin-in-oncology/apigenin-evidence-by-cancer-type.md).

# Apigenin Evidence by Cancer Type

## Apigenin Evidence by Cancer Type

This page maps the cancer types where apigenin has enough independent evidence to justify closer review. Additional pages can be added as the literature grows.

### Dedicated pages

| Cancer Type                 | Why It Matters                                                                                                  | Evidence Level                                     |
| --------------------------- | --------------------------------------------------------------------------------------------------------------- | -------------------------------------------------- |
| Colorectal Cancer           | PKM2 glycolysis, BCL-2 family pressure, `Wnt/β-catenin`, cisplatin resistance, colitis-associated cancer models | One of the strongest settings                      |
| Hepatocellular Carcinoma    | `PI3K/AKT`, sorafenib and doxorubicin sensitisation, anti-metastatic activity in animal models                  | Strong in vivo signal                              |
| Prostate Cancer             | Akt inactivation, `IKKα/NF-κB`, androgen-refractory models, xenograft data, EMT suppression                     | One of the most mechanistically developed settings |
| Ovarian Cancer              | `MCL-1` downregulation in cisplatin-resistant cells, specific resistance-reversal mechanism                     | Clinically interesting                             |
| Haematological Malignancies | Topoisomerase inhibitor sensitisation in leukaemia, ferroptosis in myeloma                                      | Early, but mechanistically distinct                |

#### Dedicated page links

* [Colorectal Cancer](/myhealingcommunity-docs/natural-medicines/apigenin-in-oncology/apigenin-evidence-by-cancer-type/colorectal-cancer.md)
* [Hepatocellular Carcinoma](/myhealingcommunity-docs/natural-medicines/apigenin-in-oncology/apigenin-evidence-by-cancer-type/hepatocellular-carcinoma.md)
* [Prostate Cancer](/myhealingcommunity-docs/natural-medicines/apigenin-in-oncology/apigenin-evidence-by-cancer-type/prostate-cancer.md)
* [Ovarian Cancer](/myhealingcommunity-docs/natural-medicines/apigenin-in-oncology/apigenin-evidence-by-cancer-type/ovarian-cancer.md)
* [Haematological Malignancies](/myhealingcommunity-docs/natural-medicines/apigenin-in-oncology/apigenin-evidence-by-cancer-type/haematological-malignancies.md)

### Other cancer types overview

Several additional tumour types show consistent cell-line signals but do not yet justify standalone pages:

* **Lung cancer (`NSCLC`):** `TRAIL` potentiation, `PI3K/AKT` effects, and early anti-metastatic signals in animal models
* **Melanoma:** `PD-L1` suppression, `STAT3` involvement, and one of the strongest immune-oncology signals across the apigenin literature
* **Breast cancer:** p53-dependent apoptosis, SASP suppression, and `IL-1α/NF-κB` relevance. This could justify a dedicated page if the evidence base continues to grow.
* **Endometrial cancer:** ferroptosis and autophagy data. Early, but mechanistically interesting.
* **Pancreatic cancer:** gemcitabine sensitisation and NK-cell cytotoxicity data. Very early and still thin.


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