# Trusted Suppliers and Discounts MCS Formulas is the natural compound producer featured across My Healing Community and the [Healing Cancer Study Support Facebook Group](/myhealingcommunity-docs/cancer-patient-community-supports/online-groups/facebook-groups/healing-cancer-study-support-facebook-group.md). {% hint style="info" %} Use code `abbey5` for **5% off** at MCS Formulas. That code also helps support Abbey's free research, study support, and community work. {% endhint %} ### A note from Abbey > All my work and investment in the new site has been made possible thanks to the support MCS Formulas provides, and to everyone who uses our Study Support Group 5% discount code at MCS Formulas: `abbey5`. Truly grateful for this win-win situation! ### Why MCS Formulas is featured here MCS Formulas is one of the most trusted cancer-focused supplement companies in the world. Its formulas are built around oncology research evidence, pure active ingredients levels, strength and bioavailability. The company was founded by scientist Daniel Stanciu, PhD. Its wider mission also matters here. MCS Formulas donates 50% of its proceeds to work aimed at improving and extending the lives of cancer patients. When you use the `abbey5` for **5% off** MCS Formulas products it supports Abbey to devote her time to the support group members, work endlessly on the research summaries on this site, cover the less visible costs behind the work, be self-employed doing what she loves most AND all the whilst living well with a metastatic cancer diagnosis. ### MCS Formulas discount Use code `abbey5` for **5% off** MCS Formulas products. Using this code also helps support My Healing Community and the free Healing Cancer Study Support resources. Use this link to shop: ### Deep dives already found here on this site These pages already contain supplier references or product links tied to MCS: * [Sourcing Quality Polydatin](/myhealingcommunity-docs/natural-medicines/polydatin-in-oncology/sourcing-quality-polydatin.md) * [Sourcing Quality Curcumin](/myhealingcommunity-docs/natural-medicines/curcumin-in-oncology/sourcing-quality-curcumin.md) * [Sourcing Quality EGCG](/myhealingcommunity-docs/natural-medicines/egcg-in-oncology/sourcing-quality-egcg.md) * [Sourcing Quality Boswellia](/myhealingcommunity-docs/natural-medicines/boswellia-in-oncology/sourcing-quality-boswellia.md) * [Sourcing Quality Urolithin A](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology/sourcing-quality-urolithin-a.md) {% hint style="info" %} **What's often in a senolytic stack** Stack pulses often include fisetin, quercetin, luteolin, apigenin, and if the person is up for more ROS, piperlongumine too. On MCS Formulas, that usually maps to **Fisetin Pro Liposomal**, **Quercetin & Bromelain**, **Luteolin Pro Liposomal**, **Apigenin Pro Liposomal**, and **Piperlongumine Pro Liposomal**.\ \ Beneath the MCS A–Z list, there is also a section on why natural compounds are often pulsed in post-treatment dormancy strategies. [Skip to that section.](#research-validated-senolytic-compounds-by-mechanis) {% endhint %} ### MCS Formulas A–Z product list This page now includes the full MCS Formulas list in one place. Prices shown here are **before** the `abbey5` discount is applied. Where this site already has a matching compound page, a `Deep dive` link is included. ### Jump to a letter [A](#a) · [B](#b) · [C](#c) · [D](#d) · [E](#e) · [F](#f) · [G](#g) · [H](#h) · [I](#i) · [L](#l) · [M](#m) · [N](#n) · [O](#o) · [P](#p) · [Q](#q) · [R](#r) · [S](#s) · [T](#t) · [U](#u) · [V](#v) · [W](#w) #### A * **Agaricus Extract** — 350 mg/capsule — €29.96 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/agaricus-extract/ref/14) * **AHCC** — 500 mg, 60 caps — €55.50 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/ahcc/ref/14) * **Apigenin Pro Liposomal** — 200 mg — €38.00 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/apigenin-pro-liposomal/ref/14) * **Ashwagandha Pure** — 400 mg/capsule — €12.75 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/ashwagandha/ref/14) * **Astragaloside IV** — 50 mg/capsule — €45.00 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/astragaloside-iv/ref/14) #### B * **Baicalein Pro Liposomal** — 200 mg — €37.60 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/baicalein-pro-liposomal/ref/14) * **Berberine Pro Liposomal** — 60 caps — €35.56 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/berberine-liposomal/ref/14) * **Berberine Pure** — 450 mg/capsule — €27.20 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/berberine/ref/14) * **Betulinic Acid Pro Liposomal** — 50 mg — €43.34 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/betulinic-acid-liposomal/ref/14) * **Black Cumin Seed Oil** — 500 mg/softgel — €16.52 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/black-cumin-seed-oil-supplement/ref/14) * **Boswellia MEGA AKBA Liposomal** — 60 caps — €37.16 * Deep dive: [Boswellia in Oncology](/myhealingcommunity-docs/natural-medicines/boswellia-in-oncology/boswellia-in-oncology-overview.md) * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/boswellia-akba-liposomal/ref/14) * **Breast Pack** * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/breast-pack/ref/14) * **Broccoli Ultra, Sulforaphane** — 60 caps — €47.00 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/broccoli-ultra-sulforaphane/ref/14) #### C * **Calcium AKG** — 120 capsules — €31.90 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/calcium-akg-500-mg/ref/14) * **Chrysin Pro Liposomal** — 250 mg — €35.81 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/chrysin-pro-liposomal/ref/14) * **Citrus Bergamot** — 500 mg/capsule — €36.50 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/citrus-bergamot/ref/14) * **CoQ10 Pro Liposomal** — 60 caps — €47.90 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/coq10-liposomal/ref/14) * **Cordyceps Liquid Extract** — €69.00 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/cordyceps-liquid-extract/ref/14) * **Coriolus (Turkey Tail)** — 350 mg/capsule — €29.37 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/coriolus-extract/ref/14) * **Curcumin C3 Pro Liposomal** — 60 caps — €38.62 * Deep dive: [Curcumin in Oncology](/myhealingcommunity-docs/natural-medicines/curcumin-in-oncology/curcumin-in-oncology-overview.md) * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/curcumin-c3-liposomal/ref/14) * **Curcumin C3** — 1000 mg/tablet — €52.95 * Deep dive: [Curcumin in Oncology](/myhealingcommunity-docs/natural-medicines/curcumin-in-oncology/curcumin-in-oncology-overview.md) * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/curcumin-c3/ref/14) #### D * **Danshen** — 500 mg — €24.32 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/danshen/ref/14) #### E * **EGCG 80%** — 400 mg/capsule — €31.70 * Deep dive: [EGCG in Oncology](/myhealingcommunity-docs/natural-medicines/egcg-in-oncology/egcg-in-oncology-overview.md) * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/egcg/ref/14) #### F * **Fisetin Pro Liposomal** — 150 mg — €39.67 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/fisetin-pro-liposomal/ref/14) #### G * **Genistein Ultra** — 250 mg/capsule — €35.40 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/genistein/ref/14) * **Glutamine Inhibifour** — 120 capsules — €47.50 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/glutamine-inhibifour/ref/14) * **Glutathione Pro Liposomal** — 200 mg — €38.25 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/glutathione-pro-liposomal/ref/14) * **Glycolysis Inhibithree** — €49.80 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/glycolysis-inhibithree/ref/14) * **Grape Seed Extract (OPC)** — 400 mg — €21.06 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/grape-seed-extract-opc/ref/14) * **Green Propolis** — 60 capsules — €40.12 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/green-propolis/ref/14) #### H * **HCA Garcinia Pure** — 510 mg/capsule — €16.50 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/hca/ref/14) * **Honokiol Pro Liposomal** — 60 caps — €37.50 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/honokiol-pro-liposomal/ref/14) * **Hydroxytyrosol** — 50 mg — €28.64 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/hydroxythyrosol/ref/14) #### I * **Inflasanum, AKBA** — 180 mg — €82.72 * Deep dive: [Boswellia in Oncology](/myhealingcommunity-docs/natural-medicines/boswellia-in-oncology/boswellia-in-oncology-overview.md) * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/inflasanum-180mg/ref/14) #### L * **Liposence Empty Liposomes** — 200 ml bottle — €125.00 * Deep dive: [How to Use Empty Liposomes](/myhealingcommunity-docs/natural-medicines/liposomal-encapsulation-of-anti-cancer-compounds.md) * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/liposence-empty-liposomes/ref/14) * **Long Pepper** — 500 mg/capsule — €19.50 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/piperlogumine/ref/14) * **Luteolin Pro Liposomal** — 150 mg — €35.50 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/luteolin-pro-liposomal/ref/14) * **Lycopene Plus** — 38 mg/capsule — €21.10 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/lycopene/ref/14) #### M * **Magnesium Gluconate** — 500 mg — €15.93 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/magnesium-gluconate/ref/14) * **Magnesium Glycinate** — 500 mg — €23.53 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/magnesium-glycinate-500mg/ref/14) * **Maitake Extract Pure** — 350 mg/capsule — €30.00 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/maitake-extract/ref/14) * **Maitake Liquid Extract** — €69.00 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/maitake-liquid-extract/ref/14) * **Mega Flaxseed Lignans** — 124 mg/capsule — €33.24 * **Milk Thistle-Silymarin** — 550 mg — €18.03 * Deep dive: [Silymarin / Milk Thistle in Oncology](/myhealingcommunity-docs/natural-medicines/silymarin-milk-thistle-in-oncology/silymarin-milk-thistle-in-oncology-overview.md) * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/milk-thistle-silymarin/ref/14) * **Modified Citrus Pectin Powder** — 450 g — €125.00 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/modified-citrus-pectin-powder/ref/14) * **Modified Citrus Pectin** — 500 mg capsules — €37.48 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/modified-citrus-pectin/ref/14) #### N * **N-Acetyl-L-Cysteine (NAC)** — 600 mg — €18.29 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/n-acetyl-l-cysteine/ref/14) * **Nattokinase 4000FU** — 200 mg — €23.30 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/nattokinase/ref/14) * **NMN Pro Liposomal** — 250 mg — €49.64 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/nmn-liposomal/ref/14) #### O * **Olive Leaf Extract** — 500 mg/capsule — €21.72 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/olive-leaf-extract/ref/14) * **Omega-3 Pure** — 700 mg DHA & EPA — €31.95 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/omega-3-fish-oil/ref/14) #### P * **Pancreas Pack** * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/pancreas-pack/ref/14) * **PEA Palmitoylethanolamide** — 60 caps, 300 mg — €33.25 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/pea-liposomal/ref/14) * **Piperlongumine Pro Liposomal** — 40 mg — €32.62 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/piperlongumine-liposomal/ref/14) * **Polydatin Pro Liposomal** — 60 caps — €43.75 * Deep dive: [Polydatin in Oncology](/myhealingcommunity-docs/natural-medicines/polydatin-in-oncology/polydatin-in-oncology-overview.md) * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/polydatin-pro-liposomal/ref/14) * **Prostate Pack** * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/prostate-pack/ref/14) * **Pure Honokiol** — 250 mg/capsule — €60.57 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/pure-honokiol/ref/14) #### Q * **Quercetin & Bromelain** — 400 mg, 100 caps — €19.32 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/quercetin-bromelain-400-mg-100-caps/ref/14) #### R * **R-Lipoic Acid** — €33.90 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/r-lipoic-acid/ref/14) * **Reishi Extract** — 350 mg/capsule — €27.00 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/reishi-extract/ref/14) * **Reishi Liquid Extract** — €69.00 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/reishi-liquid-extract/ref/14) * **Rosmarinic Acid** — €43.61 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/rosmarinic-acid-pro-liposomal/ref/14) #### S * **Scutellaria Extract** — 500 mg/capsule — €22.93 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/scutellaria-skullcap/ref/14) * **Shiitake Liquid Extract** — €69.00 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/shiitake-liquid-extract/ref/14) * **Shikonin Pro Liposomal (LongLifeLipoTech™)** — €38.92 * Deep dive: [Shikonin in Oncology](/myhealingcommunity-docs/natural-medicines/shikonin-in-oncology.md) * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/shikonin-liposomal/ref/14) * **Spermidine Pro Liposomal** — 60 caps — €44.95 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/spermidine-pro-liposomal/ref/14) * **Super Artemis** — 60 capsules — €37.58 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/artemisinin-artemisia-annua/ref/14) * **Super Green Tea Extract** — 580 mg/capsule — €24.95 * Deep dive: [EGCG in Oncology](/myhealingcommunity-docs/natural-medicines/egcg-in-oncology/egcg-in-oncology-overview.md) * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/green-tea-extract-egcg/ref/14) #### T * **Trans Resveratrol Liposomal** — 250 mg — €41.50 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/trans-resveratrol-liposomal/ref/14) * **TUDCA** — 250 mg — €29.85 * **Turkey Tail - (Coriolus)** — 350 mg/capsule — €29.37 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/coriolus-extract/ref/14) #### U * **Ultra-TQ Thymoquinone** — 60 capsules — €29.56 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/thymoquinone/ref/14) * **Urolithin A** — 60 capsules — €55.79 * Deep dive: [Urolithin A in Oncology](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology.md) * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/urolithin-a/ref/14) #### V * **Vitamin C Pro Liposomal** — 500 mg — €29.95 * Purchase: [MCS product page](https://www.mcsformulas.com/en/vitamins-supplements/vitamin-c-liposomal/ref/14) * **Vitamin D3 & K2 Liquid Drops** — €28.50 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/vitamin-d-k2-liquid/ref/14) * **Vitamin D3 Liquid Drops** — €14.94 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/vitamin-d-liquid/ref/14) #### W * **Withaferin Pro Liposomal** — €40.54 * Purchase: [MCS product page](https://www.mcsformulas.com/vitamins-supplements/withaferin-a-pro-liposomal/ref/14) *** ### Research-Validated Senolytic Compounds by Mechanism *Note: The following categorization is based on published research mechanisms. Product names and availability through MCS Formulas are listed for convenience only. All therapeutic decisions should be made in consultation with qualified healthcare providers.* Use the category headings to scan by mechanism. Use the compound headings to compare options within each group. *** #### Category 1: BCL-2/BCL-xL Anti-Apoptotic Pathway Inhibitors **Mechanism:** These are the best-validated natural senolytics in current research. Senescent cells over-express BCL-2 family proteins (BCL-2, BCL-xL, BCL-W) to resist apoptosis — these compounds block those survival shields and force dormant cancer cells into apoptosis. **Fisetin (liposomal, 150 mg) ⭐ Highest priority** The most extensively validated natural senolytic — comparable in animal studies to pharmaceutical agents like navitoclax. Selectively induces apoptosis in senescent cells via BCL-xL inhibition. Currently in Phase II clinical trial specifically for breast cancer survivors post-chemotherapy to address TIS. *Available as:* [*Fisetin Pro Liposomal* ](https://www.mcsformulas.com/vitamins-supplements/fisetin-pro-liposomal/ref/14)*at MCS Formulas* **Quercetin (with Bromelain, 400 mg) ⭐ Core senolytic** One of the first identified natural senolytics (the D+Q combination). Acts on multiple BCL-2 family pro-survival pathways in senescent cells; also well-studied combined with dasatinib in research settings. Bromelain adds anti-inflammatory synergy. *Available as:* [*Quercetin & Bromelain*](https://www.mcsformulas.com/vitamins-supplements/quercetin-bromelain-400-mg-100-caps/ref/14) *at MCS Formulas* **Apigenin (liposomal, 200 mg)** Upregulates pro-apoptotic Bax and downregulates BCL-2/Mcl-1 in cancer cells, shifting the balance toward apoptosis. Synergises with BCL-2 inhibitors (ABT-263 class) in colorectal cancer models — effectively amplifying their senolytic action. *Available as:* [*Apigenin Pro Liposomal*](https://www.mcsformulas.com/vitamins-supplements/apigenin-pro-liposomal/ref/14) *at MCS Formulas* **Luteolin (liposomal, 150 mg)** A flavone closely related to apigenin with overlapping BCL-2 family modulation and SASP suppression. Acts on NF-κB (a SASP driver) and induces mitochondria-dependent apoptosis in senescent/cancer cells. *Available as:* [*Luteolin Pro Liposomal*](https://www.mcsformulas.com/vitamins-supplements/luteolin-pro-liposomal/ref/14) *at MCS Formulas* *** #### Category 2: ROS-Mediated Senolytics — Oxidative Stress Exploitation **Mechanism:** Senescent cancer cells often have elevated baseline ROS and depleted antioxidant reserves. These compounds exploit that vulnerability by further raising ROS to lethal levels — a threshold that normal cells don't cross. **Piperlongumine (liposomal, 40 mg) ⭐ Core senolytic** One of the original validated senolytics. Kills senescent cells primarily through ROS elevation and glutathione depletion. The effect is reversed by NAC, confirming the ROS mechanism as central. Liposomal form is preferred for bioavailability. *Available as:* [*Piperlongumine Pro Liposomal*](https://www.mcsformulas.com/vitamins-supplements/piperlongumine-liposomal/ref/14) *at MCS Formulas* **Piperlongumine (whole herb source, 500 mg)** The natural whole-herb source of piperlongumine — a budget alternative or adjunct to the concentrated liposomal form. Lower active compound concentration. *Available as:* [*Long Pepper*](https://www.mcsformulas.com/en/vitamins-supplements/piperlogumine/ref/14) *at MCS Formulas* **Baicalein (liposomal, 200 mg)** Induces apoptosis in colon cancer cells via MAPK ERK/p38 signalling, and separately drives cancer cell senescence via the baicalin/telomerase route. The dual apoptotic + senescence-induction profile is unique in this category. *Available as:* [*Baicalein Pro Liposomal*](https://www.mcsformulas.com/vitamins-supplements/baicalein-pro-liposomal/ref/14) *at MCS Formulas* **Withaferin A (liposomal) ⭐ Cancer stem cell (CSC) specialist** Particularly important for dormancy because cancer stem cells (CSCs) are the most likely dormant population to re-emerge. Withaferin A preferentially kills CSCs over bulk tumour cells, via CXCR4/STAT3/IL-6 axis disruption — pathways that govern stemness and immune evasion. Combines well with conventional therapy. *Available as:* [*Withaferin Pro Liposomal*](https://www.mcsformulas.com/vitamins-supplements/withaferin-a-pro-liposomal/ref/14) *at MCS Formulas* *** #### Category 3: mTOR/AMPK Pathway Senolytics — Senescence Conversion Blockers **Mechanism:** These agents block "geroconversion" — the process by which cell cycle arrest deepens into full irreversible senescence and SASP production — by inhibiting mTOR and activating AMPK. They reduce the production of new senescent cells and can eliminate existing ones. **Berberine (liposomal or standard, 450 mg) ⭐** Operates as an mTOR inhibitor that suppresses geroconversion, reduces p16/p21 senescence markers, and promotes apoptosis in senescent cancer cells via BCL-2/Bax modulation. Also confirmed as having direct senolytic effects in UV-damaged fibroblast models. Liposomal form preferred for absorption. Deep dive: [Berberine in Oncology](/myhealingcommunity-docs/natural-medicines/berberine-in-oncology.md) *Available as:* [*Berberine Pro Liposomal*](https://www.mcsformulas.com/vitamins-supplements/berberine-liposomal/ref/14) *or* [*Berberine Pure*](https://www.mcsformulas.com/en/vitamins-supplements/berberine/ref/14) *at MCS Formulas* **EGCG (80% extract, 400 mg or green tea extract) ⭐** Acts as a multi-pronged senolytic: inhibits mTOR, suppresses BCL-2 accumulation in senescent cells, modulates SASP, and promotes apoptosis via the intrinsic mitochondrial pathway. One of the most evidence-rich natural compounds in this entire category. Deep dive: [EGCG in Oncology](/myhealingcommunity-docs/natural-medicines/egcg-in-oncology/egcg-in-oncology-overview.md) *Available as:* [*EGCG 80%*](https://www.mcsformulas.com/vitamins-supplements/egcg/ref/14) *or* [*Super Green Tea Extract*](https://www.mcsformulas.com/en/vitamins-supplements/green-tea-extract-egcg/ref/14) *at MCS Formulas* **Curcumin C3 Complex (liposomal) ⭐** Listed explicitly as a natural senolytic in the PMC discovery literature. Inhibits BCL-2 and NF-κB (a major SASP transcription factor), and inhibits mTOR. EGCG + curcumin together show synergistic BCL-2 inhibition. Liposomal form is critical for bioavailability. Deep dive: [Curcumin in Oncology](/myhealingcommunity-docs/natural-medicines/curcumin-in-oncology/curcumin-in-oncology-overview.md) *Available as:* [*Curcumin C3 Pro Liposomal*](https://www.mcsformulas.com/vitamins-supplements/curcumin-c3-liposomal/ref/14) *at MCS Formulas* *** #### Category 4: SASP Suppressors / Senomorphics — Microenvironment Cleaners **Mechanism:** These don't primarily kill senescent cells but powerfully suppress the SASP inflammatory output — reducing the pro-tumorigenic signals that senescent cells broadcast to their neighbours. Critical for controlling dormancy-to-proliferation re-awakening. **Polydatin (liposomal, 60 caps)** Trans-resveratrol precursor with superior bioavailability. Induces apoptosis via cytochrome c release and caspase-3 activation, and inhibits EMT (epithelial-mesenchymal transition) — directly targeting mechanisms of dormancy escape and metastatic re-emergence. Deep dive: [Polydatin in Oncology](/myhealingcommunity-docs/natural-medicines/polydatin-in-oncology/polydatin-in-oncology-overview.md) *Available as:* [*Polydatin Pro Liposomal*](https://www.mcsformulas.com/vitamins-supplements/polydatin-pro-liposomal/ref/14) *at MCS Formulas* **Trans-Resveratrol (liposomal, 250 mg)** Targets senescent cancer-associated fibroblasts (CAFs) in the tumour microenvironment, reduces SASP factors, and disrupts pro-tumorigenic signalling. Particularly relevant in breast cancer stroma interactions. *Available as:* [*Trans Resveratrol Liposomal*](https://www.mcsformulas.com/vitamins-supplements/trans-resveratrol-liposomal/ref/14) *at MCS Formulas* **Boswellia AKBA (liposomal)** AKBA inhibits NF-κB — one of the master regulators of SASP production. Reduces inflammatory cytokine output from senescent cells in the microenvironment without needing to directly kill them. Deep dive: [Boswellia in Oncology](/myhealingcommunity-docs/natural-medicines/boswellia-in-oncology/boswellia-in-oncology-overview.md) *Available as:* [*Boswellia MEGA AKBA Liposomal*](https://www.mcsformulas.com/vitamins-supplements/boswellia-akba-liposomal/ref/14) *at MCS Formulas* **Urolithin A (60 capsules)** Evidence clarifies this is primarily senomorphic (suppresses SASP/IL-1β/MCP-1 output) rather than directly senolytic. However it induces cancer cell senescence (a pro-senescence strategy to arrest cancer proliferation) and inhibits CSC properties, clonogenic growth, and invasion in colorectal cancer models. Best understood as a SASP modulator + mitophagy activator. Deep dive: [Urolithin A in Oncology](/myhealingcommunity-docs/natural-medicines/urolithin-a-in-oncology.md) *Available as:* [*Urolithin A*](https://www.mcsformulas.com/vitamins-supplements/urolithin-a/ref/14) *at MCS Formulas* *** #### Category 5: Supporting / Adjunct Roles These have relevant activity but are better described as supporting the senolytic strategy rather than leading it. **Spermidine (liposomal, 60 caps)** Autophagy activator (mitophagy); helps clear damaged/senescent cellular debris. Synergistic with direct senolytics. *Available as:* [*Spermidine Pro Liposomal*](https://www.mcsformulas.com/vitamins-supplements/spermidine-pro-liposomal/ref/14) *at MCS Formulas* **Silymarin/Milk Thistle (550 mg)** Silymarin has BCL-2 modulatory and NF-κB suppression activity; supports liver clearance during senolytic cell die-off (critical for managing senolytic cell burden). Deep dive: [Silymarin / Milk Thistle in Oncology](/myhealingcommunity-docs/natural-medicines/silymarin-milk-thistle-in-oncology/silymarin-milk-thistle-in-oncology-overview.md) *Available as:* [*Milk Thistle-Silymarin*](https://www.mcsformulas.com/en/vitamins-supplements/milk-thistle-silymarin/ref/14) *at MCS Formulas* **Vitamin D3 + K2 (liquid drops)** Vitamin D3 modulates senescent cell immune surveillance; low D3 is correlated with impaired clearance of senescent cells by NK cells. *Available as:* [*Vitamin D3 & K2 Liquid Drops*](https://www.mcsformulas.com/vitamins-supplements/vitamin-d-k2-liquid/ref/14) *at MCS Formulas* **N-Acetyl-L-Cysteine / NAC (600 mg)** **Important caveat:** NAC reverses the ROS-mediated activity of piperlongumine, so should **not** be co-administered with Category 2 agents. Useful at separate times for general oxidative load management. *Available as:* [*N-Acetyl-L-Cysteine*](https://www.mcsformulas.com/vitamins-supplements/n-acetyl-l-cysteine/ref/14) *at MCS Formulas* *** #### Research-Based Priority Ranking *Based on strength of senolytic evidence in peer-reviewed literature* | Compound | Mechanism Category | Research Priority | | ----------------------------- | ---------------------------- | ----------------- | | Fisetin (liposomal) | BCL-2/BCL-xL senolytic | ⭐⭐⭐ | | Quercetin & Bromelain | BCL-2/BCL-xL senolytic | ⭐⭐⭐ | | Piperlongumine (liposomal) | ROS senolytic | ⭐⭐⭐ | | Withaferin A (liposomal) | CSC-targeting senolytic | ⭐⭐⭐ | | Curcumin C3 (liposomal) | mTOR/BCL-2 senolytic | ⭐⭐⭐ | | EGCG 80% | mTOR/BCL-2 senolytic | ⭐⭐⭐ | | Berberine (liposomal) | mTOR/AMPK senolytic | ⭐⭐ | | Apigenin (liposomal) | BCL-2 senolytic | ⭐⭐ | | Polydatin (liposomal) | Senomorphic + EMT inhibitor | ⭐⭐ | | Baicalein (liposomal) | ROS + senescence inducer | ⭐⭐ | | Trans Resveratrol (liposomal) | SASP suppressor (CAF/TME) | ⭐⭐ | | Urolithin A | SASP senomorphic + mitophagy | ⭐⭐ | | Boswellia MEGA AKBA | NF-κB/SASP suppressor | ⭐ | | Spermidine (liposomal) | Autophagy/mitophagy support | ⭐ | *** #### Important Timing Consideration **NAC and ROS-dependent senolytics:** If piperlongumine or other ROS-dependent agents (Category 2) are included in a protocol, NAC should be time-separated by at least 12 hours, as it directly reverses their senolytic mechanism. #### Understanding Senolytics in Cancer Dormancy Management *This is educational content which represents current peer-reviewed research on senolytic compounds and their mechanisms. This information is provided for educational purposes and does not constitute medical advice. Product availability and formulations are listed for reference only.* **What "Senolytic" Means in a Cancer Dormancy Context** After therapy, a population of cancer cells can enter **therapy-induced senescence (TIS)** — a dormant, non-dividing state that is not dead. These cells survive via upregulated pro-survival (anti-apoptotic) pathways and secrete a **SASP (Senescence-Associated Secretory Phenotype)** — a cocktail of inflammatory cytokines and growth factors that if left unchecked can remodel the tumour microenvironment, fuel inflammation, and eventually allow dormant cells to re-emerge. **A senolytic stack pulsed in periodiclally** selectively eliminates these senescent/dormant cells, while **senomorphics** dampen the SASP without killing the cells. Both have roles in a cancer dormancy post-treatment management strategy.\ \ See the [Senescence Resource Hub ](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/endocrine-therapy-resistance-and-dormancy/autophagy-and-senescence-in-antiestrogen-resistance/senescence-the-second-escape-route.md)for a deeper dive into this topic. *** #### References **Senolytics: charting a new course or enhancing existing anti-tumor therapies**\ **Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy**\ **New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors**\ **A phase II randomized placebo-controlled study of fisetin to improve physical function in breast cancer survivors**\ **Withaferin A targeting both cancer stem cells and metastatic cancer stem cells**\ **Withaferin A inhibits tumor growth and metastasis by targeting ovarian cancer stem cells**\ **Epigallocatechin gallate and curcumin inhibit Bcl-2**\ **Berberine ameliorates cellular senescence and extends lifespan**\ **Apigenin in cancer therapy: anti-cancer effects and mechanisms of action**\ **Discovery of piperlongumine as a potential novel lead for the development of senolytic agents**\ **Polydatin, a Glycoside of Resveratrol, Induces Apoptosis and Cell Cycle Arrest**\ **Resveratrol: A promising agent in targeting senescent cancer cells**\ **Urolithin A Alleviates Doxorubicin-Induced Senescence**\ **Unveiling the Anticancer Potential of Urolithin A in Colorectal Cancer**\ **Recent advances in the discovery of senolytics**\ **Senolytic drugs: from discovery to translation**\ *** *Disclaimer: This content is for educational purposes only and does not constitute medical advice. All therapeutic decisions should be made in consultation with qualified healthcare providers. Product availability information is provided for reference only and does not constitute an endorsement or therapeutic claim.*
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