Breast Cancer Pathways Project
Breast cancer pathways worksheets, download guidance, support links, and getting-started pages
Including a free download of the latest worksheet
Released June 2021 and updated regularly.
What this project is
This project presents a structured framework to help breast cancer survivors and their clinicians organise a current protocol of off-label drugs and supplements based on a summary of available evidence.
Cancer is complex, and many pathways influence multiple hallmarks simultaneously. For simplicity, each pathway has been placed under one hallmark within the worksheet, but the biology often overlaps.
This is not intended as an exhaustive catalogue of all available evidence. New research is constantly being added to PubMed, and many useful studies may still be missing from the worksheet at any given time.
How the worksheet is organised
The worksheet is organised into pages that reflect major hallmarks of cancer, plus a resources section for readers who want to go further.
These pages include:
Manipulate Signaling
Dysregulate Metabolism
Invade / Metastasise
Evade Immune System
Achieve Immortality
Avoid Death
Eliminate Cancer Stem Cells
Resources
In Loving Memory
This project is dedicated to Lauren Gue, whose research on breast cancer phenotypes helped inspire this work.
These freely shared breast cancer pathway worksheets honour the memory of Lauren, Sarah, Melanie and others whose curiosity, courage, and research spirit continue to help this community.
Created by Maria Wessling Bachteal and Abbey Mitchell, with help from members and contributors across the wider healing community.
Quick video preview: Insert video embed link here
"Cancer doesn't happen in a vacuum. It's important to consider the larger environment in which cancer develops."
Have you considered working with a certified cancer terrain advocate to address the broader terrain in which cancer has developed?
Acknowledgements
These breast cancer pathways are based in part on the ground-breaking work of Douglas Hanahan and Robert Weinberg on the hallmarks of cancer, and were also inspired by Jane McLelland's work on metabolic and pathway-based thinking.
At the time this project was initiated, the work of the following practitioners and researchers (in no particular order) also supported off-label drugs for cancer, the use of bioavailable natural compounds, and integrative thinking about cancer's metabolic and signalling pathway-based strategies.
Neil McKinney, ND
Keith Block, MD
Daniel Thomas, MD / DO
Brian Lawenda, MD
Donnie Yance, MH, CN, RH (AHG)
Lise Alschuler, ND, FABNO
Dwight McKee, MD
Gurdev Parmar, ND, FABNO
Jason Miller, DACM, LAc
Nalini Chilkov, OMD, LAc
Tina Kaczor, ND, FABNO
Kristin Wohlschlagel, RN
Valter Longo, PhD
Dominic D'Agostino, PhD
Dr Nasha Winters, FABNO
Safety first
The information presented in the worksheets is not medical advice. Please consult a qualified healthcare professional before making changes to treatment, medication, supplements, or diet.
The information provided here is not meant to be prescriptive. It is intended as a guide to help you and your integrative cancer practitioner work within the context of your standard-of-care oncology protocol.
The worksheet summarises research available in the public database PubMed. The strength of the evidence varies by pathway and by substance. In many cases, only in vitro evidence is available and the effects in humans remain unknown.
Most of the information summarised in the worksheet comes from pre-clinical research
Human research into many off-label drugs and supplements remains rare because the financial incentive to fund it is often low
Some herbs, nutrients, and off-label agents may affect the bioavailability or side effects of certain drugs because of P450 enzyme interactions
In practice, integrative cancer practitioners use off-label drugs, supplements, and therapies within broader clinical protocols to support the effectiveness or tolerability of conventional treatment
The worksheet should not be treated as a prescriptive laundry list
We encourage readers to seek help from an integrative cancer practitioner who can put the research into clinical context and help build the most appropriate plan for the individual situation.
Download the worksheet
Before downloading, please delete any older versions of the worksheet or previous copies to avoid confusion.
Open the Breast Cancer Pathways Worksheet
This opens the worksheet in Google Sheets so you can make your own copy.
The worksheet should open in a new browser tab linked to Google Sheets and look like this (image below). Click on the blue MAKE A COPY button. If it does not open this way, you may need to be logged in to your Google Account ( think Gmail) on the device you are downloading the worksheet to for it to work.
Getting Started
Step 1 — Download the Worksheet
Before downloading, please delete any existing versions of the worksheet or previous copies if you want to avoid confusion.
Clicking the link below should open the worksheet in a new browser tab linked to Google Sheets.
Open the Breast Cancer Pathways Worksheet
Steps to save your copy
Sign in to your Google account if prompted
Open your Google Drive
Select Make a Copy of the worksheet so you create your own editable version
Rename your copy with your name and the date
Golden rule: always copy and rename the worksheet before making changes to it.
Want a hard copy?
Download the individual sheets as PDF files first
Add page breaks where needed before printing
Avoid printing directly from Google Drive if formatting becomes awkward
Need technical help?
Provide Worksheet Feedback (Insert feedback form link here)
Step 2 — Explore Your Worksheet
Once your personal copy is open in Google Sheets, take a few minutes to explore the tabs and structure before entering information.
Key things to know
navigation tabs appear at the bottom of the screen
begin with the tab titled Enter Master Data
use the pull-down menus where provided
Do not edit the text in Column A or Column B on the worksheet tabs. These columns contain the core structure and formulas. You are free to write notes in columns to the right of Column B.
Navigating on a mobile device
the navigation tabs may disappear when you scroll down
if menus vanish, tap the small tick symbol at the top-left to restore editing view
Understanding the worksheet scope
The worksheet has been expanded to include concepts from the original hallmarks of cancer work and later pathway-based thinking, so it may feel bigger than expected at first glance.
Step 3 — Standard of Care Choices
The Enter Master Data tab is the starting point for recording current treatment choices.
What standard of care means here
Standard of care refers to the conventional oncology treatments recommended by your treating team, such as:
surgery
chemotherapy
targeted therapy
hormone therapy
radiotherapy
immunotherapy
How the auto-fill works
Once you select your standard-of-care choices, the worksheet automatically populates relevant sections elsewhere.
This is why it is important not to edit Column A or Column B on the worksheet tabs. Those columns support the worksheet logic.
Working with an integrative practitioner
The worksheet is designed as a conversation tool, not a prescription list.
Use it with a practitioner to help:
prioritise the most relevant pathways
review interaction risks
build a more personalised and safer support plan
Step 4 — Typical Dosages
The dosage information in the worksheet is provided as a general research guide only. It is not a prescription.
How to interpret dosage information
The worksheet summarises dosage ranges drawn from research available in the public literature.
That means:
some entries are based only on in vitro work
some include in vivo animal data
fewer have direct human clinical dosing data
Important considerations
some compounds affect CYP or other drug-handling pathways
the worksheet should not be treated as a list of things to take all at once
human research into many off-label drugs and supplements is limited for practical funding reasons
Recommended next step
Take the populated worksheet to an integrative practitioner and review the evidence in context rather than acting on the dosage column alone.
Step 5 — Sharing Your Worksheet
Sharing your personal copy of the worksheet with practitioners or trusted supporters can make the process more collaborative.
How to share
Open your personal copy in Google Sheets
Click the Share button in the top-right corner
Enter the email address of the person you want to share with
Choose the permission level carefully
Click Send
You can also use Copy link and adjust access settings if needed.
A good default is to share as Viewer with your oncologist or GP, so they can see the research structure without accidentally changing your worksheet.
Join the community
Breast Cancer Pathways Research Sharing Community (Insert Facebook group link here)
Healing Cancer Study Support Group (Insert Facebook group link here)
Popular Articles & Research — MHC Blog (Insert blog link here)
Feeling overwhelmed?
Take a break. EFT or tapping may help support your capacity to absorb what is useful and let go of what is too much for today.
Appreciation & gratitude
Special thanks to Steve Cossell, Jayde Simpson, Debbie Hayes, Riki Rose, Arpan Talwar, and the wider community who helped shape and share this work.
Community & Support
Breast Cancer Pathways Research Sharing Community
Join the dedicated Facebook group for ongoing research sharing and discussion.
Join or Login to the Facebook Group (Insert Breast Cancer Pathways Facebook group link here)
Healing Cancer Study Support Group
A cancer community that is hope-focused, science-driven.
Founded by Abbey Mitchell, this private Facebook group makes researching the many topics and support strategies easier in the community.
Join the Healing Cancer Study Support Group (Insert Facebook group link here)
Gratitude
Special thanks to Steve Cossell, Jayde Simpson, Debbie Hayes, Riki Rose, Arpan Talwar, and others who contributed time, thought, and support.
This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use.
© 2026 Abbey Mitchell. All rights reserved. Please share by URL rather than copying page text.
Last updated
Was this helpful?