# Breast Cancer Pathways Project ### Including a free download of the latest worksheet Released June 2021 and updated regularly. ### What this project is This project presents a structured framework to help breast cancer survivors and their clinicians organise a current protocol of off-label drugs and supplements based on a summary of available evidence. Cancer is complex, and many pathways influence multiple hallmarks simultaneously. For simplicity, each pathway has been placed under one hallmark within the worksheet, but the biology often overlaps. This is not intended as an exhaustive catalogue of all available evidence. New research is constantly being added to PubMed, and many useful studies may still be missing from the worksheet at any given time. ### How the worksheet is organised The worksheet is organised into pages that reflect major **hallmarks of cancer**, plus a resources section for readers who want to go further. These pages include: * Manipulate Signaling * Dysregulate Metabolism * Invade / Metastasise * Evade Immune System * Achieve Immortality * Avoid Death * Eliminate Cancer Stem Cells * Resources ### In Loving Memory This project is dedicated to **Lauren Gue**, whose research on breast cancer phenotypes helped inspire this work. These freely shared breast cancer pathway worksheets honour the memory of Lauren, Sarah, Melanie and others whose curiosity, courage, and research spirit continue to help this community. Created by **Maria Wessling Bachteal** and **Abbey Mitchell**, with help from members and contributors across the wider healing community. > **Quick video preview:** *Insert video embed link here* > *"Cancer doesn't happen in a vacuum. It's important to consider the larger environment in which cancer develops."* Have you considered working with a certified cancer terrain advocate to address the broader terrain in which cancer has developed? ### Acknowledgements These breast cancer pathways are based in part on the ground-breaking work of **Douglas Hanahan** and **Robert Weinberg** on the hallmarks of cancer, and were also inspired by **Jane McLelland's** work on metabolic and pathway-based thinking. At the time this project was initiated, the work of the following practitioners and researchers *(in no particular order)* also supported off-label drugs for cancer, the use of bioavailable natural compounds, and integrative thinking about cancer's metabolic and signalling pathway-based strategies. * Neil McKinney, ND * Keith Block, MD * Daniel Thomas, MD / DO * Brian Lawenda, MD * Donnie Yance, MH, CN, RH (AHG) * Lise Alschuler, ND, FABNO * Dwight McKee, MD * Gurdev Parmar, ND, FABNO * Jason Miller, DACM, LAc * Nalini Chilkov, OMD, LAc * Tina Kaczor, ND, FABNO * Kristin Wohlschlagel, RN * Valter Longo, PhD * Dominic D'Agostino, PhD * Dr Nasha Winters, FABNO ### Safety first {% hint style="warning" %} The information presented in the worksheets is not medical advice. Please consult a qualified healthcare professional before making changes to treatment, medication, supplements, or diet. {% endhint %} **The information provided here is *****not***** meant to be prescriptive.** It is intended as a guide to help you and your integrative cancer practitioner work within the context of your standard-of-care oncology protocol. The worksheet summarises research available in the public database PubMed. The strength of the evidence varies by pathway and by substance. In many cases, only **in vitro** evidence is available and the effects in humans remain unknown. * Most of the information summarised in the worksheet comes from **pre-clinical research** * Human research into many off-label drugs and supplements remains rare because the financial incentive to fund it is often low * Some herbs, nutrients, and off-label agents may affect the bioavailability or side effects of certain drugs because of **P450 enzyme interactions** * In practice, integrative cancer practitioners use off-label drugs, supplements, and therapies within broader clinical protocols to support the effectiveness or tolerability of conventional treatment * The worksheet should **not** be treated as a prescriptive laundry list We encourage readers to seek help from an integrative cancer practitioner who can put the research into clinical context and help build the most appropriate plan for the individual situation. ### Download the worksheet {% hint style="info" %} Before downloading, please delete any older versions of the worksheet or previous copies to avoid confusion. {% endhint %}

Open the Breast Cancer Pathways Worksheet

This opens the worksheet in Google Sheets so you can make your own copy. The worksheet should open in a new browser tab linked to Google Sheets and look like this (image below). Click on the blue **MAKE A COPY** button.\ If it does not open this way, you may need to be logged in to your Google Account ( think Gmail) on the device you are downloading the worksheet to for it to work.
### Getting Started
Step 1 — Download the Worksheet {% hint style="danger" %} Before downloading, please delete any existing versions of the worksheet or previous copies if you want to avoid confusion. {% endhint %} Clicking the link below should open the worksheet in a new browser tab linked to Google Sheets. Open the Breast Cancer Pathways Worksheet #### Steps to save your copy 1. Sign in to your Google account if prompted 2. Open your Google Drive 3. Select **Make a Copy** of the worksheet so you create your own editable version 4. Rename your copy with your name and the date {% hint style="info" %} Golden rule: always copy and rename the worksheet before making changes to it. {% endhint %} #### Want a hard copy? * Download the individual sheets as PDF files first * Add page breaks where needed before printing * Avoid printing directly from Google Drive if formatting becomes awkward #### Need technical help? [Provide Worksheet Feedback](#) *(Insert feedback form link here)*
Step 2 — Explore Your Worksheet Once your personal copy is open in Google Sheets, take a few minutes to explore the tabs and structure before entering information. #### Key things to know * navigation tabs appear at the bottom of the screen * begin with the tab titled **Enter Master Data** * use the pull-down menus where provided {% hint style="warning" %} Do not edit the text in Column A or Column B on the worksheet tabs. These columns contain the core structure and formulas. You are free to write notes in columns to the right of Column B. {% endhint %} #### Navigating on a mobile device * the navigation tabs may disappear when you scroll down * if menus vanish, tap the small tick symbol at the top-left to restore editing view #### Understanding the worksheet scope The worksheet has been expanded to include concepts from the original hallmarks of cancer work and later pathway-based thinking, so it may feel bigger than expected at first glance.
Step 3 — Standard of Care Choices The **Enter Master Data** tab is the starting point for recording current treatment choices. #### What standard of care means here Standard of care refers to the conventional oncology treatments recommended by your treating team, such as: * surgery * chemotherapy * targeted therapy * hormone therapy * radiotherapy * immunotherapy #### How the auto-fill works Once you select your standard-of-care choices, the worksheet automatically populates relevant sections elsewhere. {% hint style="info" %} This is why it is important not to edit Column A or Column B on the worksheet tabs. Those columns support the worksheet logic. {% endhint %} #### Working with an integrative practitioner The worksheet is designed as a conversation tool, not a prescription list. Use it with a practitioner to help: * prioritise the most relevant pathways * review interaction risks * build a more personalised and safer support plan
Step 4 — Typical Dosages {% hint style="warning" %} The dosage information in the worksheet is provided as a general research guide only. It is not a prescription. {% endhint %} #### How to interpret dosage information The worksheet summarises dosage ranges drawn from research available in the public literature. That means: * some entries are based only on in vitro work * some include in vivo animal data * fewer have direct human clinical dosing data #### Important considerations * some compounds affect CYP or other drug-handling pathways * the worksheet should not be treated as a list of things to take all at once * human research into many off-label drugs and supplements is limited for practical funding reasons #### Recommended next step Take the populated worksheet to an integrative practitioner and review the evidence in context rather than acting on the dosage column alone.
Step 5 — Sharing Your Worksheet Sharing your personal copy of the worksheet with practitioners or trusted supporters can make the process more collaborative. #### How to share 1. Open your personal copy in Google Sheets 2. Click the **Share** button in the top-right corner 3. Enter the email address of the person you want to share with 4. Choose the permission level carefully 5. Click **Send** You can also use **Copy link** and adjust access settings if needed. {% hint style="info" %} A good default is to share as **Viewer** with your oncologist or GP, so they can see the research structure without accidentally changing your worksheet. {% endhint %} #### Join the community * [Breast Cancer Pathways Research Sharing Community](#) *(Insert Facebook group link here)* * [Healing Cancer Study Support Group](#) *(Insert Facebook group link here)* * [Popular Articles & Research — MHC Blog](#) *(Insert blog link here)* #### Feeling overwhelmed? Take a break. EFT or tapping may help support your capacity to absorb what is useful and let go of what is too much for today. #### Appreciation & gratitude Special thanks to **Steve Cossell, Jayde Simpson, Debbie Hayes, Riki Rose, Arpan Talwar**, and the wider community who helped shape and share this work.
### Community & Support #### Breast Cancer Pathways Research Sharing Community Join the dedicated Facebook group for ongoing research sharing and discussion. [Join or Login to the Facebook Group](#) *(Insert Breast Cancer Pathways Facebook group link here)* #### Healing Cancer Study Support Group *A cancer community that is hope-focused, science-driven.* Founded by Abbey Mitchell, this private Facebook group makes researching the many topics and support strategies easier in the community. [Join the Healing Cancer Study Support Group](#) *(Insert Facebook group link here)* *** ### Gratitude Special thanks to **Steve Cossell, Jayde Simpson, Debbie Hayes, Riki Rose, Arpan Talwar**, and others who contributed time, thought, and support. {% hint style="warning" %} This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use. {% endhint %} {% hint style="info" %} © 2026 Abbey Mitchell. All rights reserved. Please share by URL rather than copying page text. {% endhint %} --- # Agent Instructions: Querying This Documentation If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question. Perform an HTTP GET request on the current page URL with the `ask` query parameter: ``` GET https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/breast-cancer/support-groups/breast-cancer-pathways-project.md?ask= ``` The question should be specific, self-contained, and written in natural language. The response will contain a direct answer to the question and relevant excerpts and sources from the documentation. Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.