# HER2CLIMB

This subgroup brings together the main pages related to the **HER2CLIMB regimen**.

Use it when you want to understand:

* why progression may happen on tucatinib, trastuzumab, and capecitabine
* what liquid biopsy may or may not detect
* whether tucatinib clearance could be altered
* whether supplements may affect CYP3A4-related drug handling

### Pages in this section

* [HER2CLIMB Guide](/myhealingcommunity-docs/breast-cancer/her2-positive/her2climb/her2climb-guide.md)
* [HER2CLIMB Resistance Mechanisms](/myhealingcommunity-docs/breast-cancer/her2-positive/her2climb/her2climb-resistance-mechanisms.md)
* [Liquid Biopsy for HER2-Positive Resistance](/myhealingcommunity-docs/breast-cancer/her2-positive/her2climb/liquid-biopsy-for-her2-positive-resistance.md)
* [Tucatinib Clearance, Genetics, and Enzyme Inducers](/myhealingcommunity-docs/breast-cancer/her2-positive/her2climb/tucatinib-clearance-genetics-and-enzyme-inducers.md)
* [Natural Compounds and CYP3A4 — HER2CLIMB Considerations](/myhealingcommunity-docs/breast-cancer/her2-positive/her2climb/natural-compounds-and-cyp3a4-her2climb-considerations.md)

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This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use.
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© 2026 Abbey Mitchell. All rights reserved. Please share by URL rather than copying page text.
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# Agent Instructions: Querying This Documentation

If you need additional information that is not directly available in this page, you can query the documentation dynamically by asking a question.

Perform an HTTP GET request on the current page URL with the `ask` query parameter:

```
GET https://myhealingcommunity.gitbook.io/myhealingcommunity-docs/breast-cancer/her2-positive/her2climb.md?ask=<question>
```

The question should be specific, self-contained, and written in natural language.
The response will contain a direct answer to the question and relevant excerpts and sources from the documentation.

Use this mechanism when the answer is not explicitly present in the current page, you need clarification or additional context, or you want to retrieve related documentation sections.