# Endocrine therapy, resistance, and dormancy

This part of the ER-positive section gathers the pages that sit closest to treatment pressure, survival under therapy, and late escape.

Use these pages together when the real question is not only **which drug comes next**, but **what surviving cells may be doing during treatment**.

### Start here

* [CDK4/6 Options and Supplement Considerations](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/endocrine-therapy-resistance-and-dormancy/cdk4-6-options-and-supplement-considerations.md)\
  Practical comparison of palbociclib, ribociclib, and abemaciclib, including monitoring and supplement-fit questions.
* [Autophagy Escape in ER-Positive Breast Cancer](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/endocrine-therapy-resistance-and-dormancy/autophagy-escape-in-er-positive-breast-cancer.md)\
  Why autophagy, mTOR pressure, glycolysis, and hydroxychloroquine keep coming up in this subtype.
* [Autophagy and Senescence in Antiestrogen Resistance](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/endocrine-therapy-resistance-and-dormancy/autophagy-and-senescence-in-antiestrogen-resistance.md)\
  Short, paced guide to the 2024 review on autophagy, reversible senescence, and acquired endocrine resistance.
* [Endocrine Therapy, Stable Disease, and Dormancy in ER-Positive Breast Cancer](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/endocrine-therapy-resistance-and-dormancy/endocrine-therapy-stable-disease-and-dormancy-in-er-positive-breast-cancer.md)\
  Why ER-positive disease can stay quiet for long periods, and why late reactivation still happens.
* [AI Resistance and the 4-OHE1/E2 Pathway](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/endocrine-therapy-resistance-and-dormancy/ai-resistance-and-the-4-ohe1-e2-pathway.md)\
  Estrogen-metabolism and resistance-handling questions that come up around aromatase-inhibitor progression.
* [Blood Biopsy Trial — Getting Ahead of Treatment Resistance](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/endocrine-therapy-resistance-and-dormancy/blood-biopsy-trial-getting-ahead-of-treatment-resistance.md)\
  How ctDNA and early ESR1 tracking may help identify resistance sooner.

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This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use.
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© 2026 Abbey Mitchell. All rights reserved. Please share by URL rather than copying page text.
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