# Breast Cancers Overview

This section is the main breast-cancer hub.

It is organised by subtype, cross-subtype pages, and practical breast-cancer support resources.

<details>

<summary>Breast Cancer **Drug and brand names used on this site**</summary>

On this site, drug names usually appear as the **generic name first**, then the **brand name in brackets**.

Brand names can vary by country.

This glossary starts with the **endocrine and ER-positive treatment names** used most often across this section.

It also includes the main **TNBC drug names** used in the **Triple-Negative** pages.

**CDK4/6 inhibitors**

* **Palbociclib** — **Ibrance** (**Pfizer**). Used with endocrine therapy in **HR-positive, HER2-negative** breast cancer.
* **Ribociclib** — **Kisqali** (**Novartis**). A CDK4/6 inhibitor with strong **overall-survival** data alongside endocrine therapy.
* **Abemaciclib** — **Verzenio** (**Eli Lilly**). A CDK4/6 inhibitor given continuously, with **overall-survival** benefit in selected settings.

**Aromatase inhibitors**

* **Anastrozole** — **Arimidex**. An aromatase inhibitor that lowers estrogen production, mainly after menopause.
* **Letrozole** — **Femara**. A common first-line endocrine therapy in postmenopausal **HR-positive** disease.
* **Exemestane** — **Aromasin**. A steroidal aromatase inhibitor often used after non-steroidal AIs or with **everolimus**.

**SERDs**

* **Fulvestrant** — **Faslodex**. An injectable **SERD** that blocks and degrades the estrogen receptor.
* **Elacestrant** — **Orserdu**. An oral **SERD** used in **ER-positive, HER2-negative, ESR1-mutated** advanced or metastatic disease after prior endocrine therapy.

**Other targeted therapies**

* **Alpelisib** — **Piqray**. A **PI3K-alpha inhibitor** used with **fulvestrant** in **PIK3CA-mutated**, **HR-positive, HER2-negative** advanced breast cancer after endocrine progression.
* **Everolimus** — **Afinitor**. An **mTOR inhibitor** used with **exemestane** in selected postmenopausal patients after prior aromatase inhibitors.

**TNBC chemotherapy backbones**

* **Doxorubicin** — **Adriamycin** and **epirubicin** — **Ellence**. Anthracyclines often paired with **cyclophosphamide** in early-stage **TNBC**.
* **Paclitaxel** — **Taxol** and **docetaxel** — **Taxotere**. Taxanes used in neoadjuvant, adjuvant, and metastatic settings.
* **Carboplatin** — **Paraplatin** and **cisplatin** — **Platinol**. Platinum drugs often considered in **TNBC**, especially with **BRCA1/2** or broader **HRD** context.

**TNBC immunotherapy**

* **Pembrolizumab** — **Keytruda**. A **PD-1 inhibitor** used with chemotherapy in selected high-risk early-stage and **PD-L1-positive** metastatic **TNBC**.

**TNBC PARP inhibitors**

* **Olaparib** — **Lynparza**. Used in selected **gBRCA1/2-mutated**, **HER2-negative** breast cancer settings.
* **Talazoparib** — **Talzenna**. Another **PARP inhibitor** used in metastatic **HER2-negative** disease with germline **BRCA** variants.

**TNBC antibody-drug conjugates**

* **Sacituzumab govitecan** — **Trodelvy**. A **TROP2-directed ADC** used in previously treated metastatic **TNBC**.

</details>

### Subtypes

* [HER2-Positive](/myhealingcommunity-docs/breast-cancer/her2-positive.md)
* [ER-Positive / HER2-Negative](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative.md)
* [AR+/ER+ Breast Cancer](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/ar+-er+-breast-cancer.md)
* [Triple-Positive](/myhealingcommunity-docs/breast-cancer/triple-positive.md)
* [Triple-Negative](/myhealingcommunity-docs/breast-cancer/triple-negative.md)

### Shared topics and project hubs

* [Endocrine Therapy, Stable Disease, and Dormancy in ER-Positive Breast Cancer](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/endocrine-therapy-resistance-and-dormancy/endocrine-therapy-stable-disease-and-dormancy-in-er-positive-breast-cancer.md): Focused explainer on why endocrine therapy can help hold ER-positive disease quiet for years, and why late dormancy escape can still happen.
* [Autophagy Escape in ER-Positive Breast Cancer](/myhealingcommunity-docs/breast-cancer/er-positive-her2-negative/endocrine-therapy-resistance-and-dormancy/autophagy-escape-in-er-positive-breast-cancer.md): Why mTOR pressure, glycolysis, dormancy, PI3K inhibition, and hydroxychloroquine come up in ER-positive/HER2-negative disease, with or without known TP53 status.
* [Support Groups](/myhealingcommunity-docs/breast-cancer/support-groups.md): Breast cancer support groups that are not subtype-specific. Sub-type-specific support groups are found in their specific hubs.
* [Breast Cancer Pathways Project](/myhealingcommunity-docs/breast-cancer/support-groups/breast-cancer-pathways-project.md)\
  Free worksheet downloads, access guidance, and breast cancer pathways-based information for structured protocol design discussions with your team.

### Support Threads and Google Docs

This quick list keeps the broader breast-cancer external resources easy to find.

* **📄 = Google Doc link**
* **💬 = Facebook group discussion thread link**

{% hint style="info" %}
Facebook links work for members of the Healing Cancer Study Support Group who are signed into Facebook on their device.
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* 💬 [Ketogenic Diet for Breast Cancer: A Paradox Unpacked](https://www.facebook.com/groups/healingcancerstudysupport/permalink/1760125704903038/)
* 💬 [Male Breast Cancer](https://www.facebook.com/groups/healingcancerstudysupport/permalink/448774289371526/)
* 💬 [Oral Vit C and Breast Cancer](https://www.facebook.com/groups/healingcancerstudysupport/permalink/1361712218077724/)
* 📄 [Radiation Post-First-Line-Chemo in Breast Cancer Doc](https://docs.google.com/document/d/e/2PACX-1vQ3I73fZQiTiRjBQtLxiwiNrt6JNkQX-vprBT4AJBgrbCFXT5NuDb6JCzMbXfJbqIMyGgi2e-ubQnR3/pub)
* 📄 [Bone Mets - Our Group's Toolkit Free Doc](https://docs.google.com/document/d/e/2PACX-1vTQb90H3YB18LpZvtKqKnmQh1yPeevnx1cpDenx_LfAmuoYqpNz_Ef7bBuCu_q_68yoci1H6BsWG-KZ/pub)
* 💬 [Collagen When Healing Breast Cancer](https://www.facebook.com/groups/healingcancerstudysupport/permalink/1548165506099060/)
* 💬 [Lobular Carcinoma - Invasive Pleomorphic](https://www.facebook.com/groups/healingcancerstudysupport/permalink/1539632850285659/)
* 💬 [Iodine Resources for Breast Tissue Healing](https://www.facebook.com/groups/healingcancerstudysupport/permalink/1764301357818806/)

### Cross-subtype pages - soon to land

These pages below are in progress.\
Please bookmark the space holder landing page and check back in a few days.

#### Biology and treatment questions

* [Post-Chemotherapy Cell Senescence Clean-up](/myhealingcommunity-docs/breast-cancer/post-chemotherapy-cell-senescence-clean-up.md)
* [Dormant Cancer Cells: How to Erase Them](/myhealingcommunity-docs/breast-cancer/dormant-cancer-cells-how-to-erase-them.md)
* [Radiation Post-First-Line Chemo? 2025 Summary](/myhealingcommunity-docs/breast-cancer/radiation-post-first-line-chemo-2025-summary.md)

#### Adjuncts and cautions

* [Ketogenic Diet for Breast Cancer: A Paradox Unpacked](/myhealingcommunity-docs/breast-cancer/ketogenic-diet-for-breast-cancer-a-paradox-unpacked.md)
* [Lactoferrin Warning in Breast Cancer](/myhealingcommunity-docs/breast-cancer/lactoferrin-warning-in-breast-cancer.md)
* [Collagen When Healing Breast Cancer](/myhealingcommunity-docs/breast-cancer/collagen-when-healing-breast-cancer.md)

#### Metastatic and support resources

* [Metastatic Disease Support](/myhealingcommunity-docs/breast-cancer/metastatic-disease-support.md)
* [Support Threads & Docs](/myhealingcommunity-docs/breast-cancer/support-threads-and-docs.md)

### How to explore this section

1. Start with the subtype that best matches the current disease context.
2. Use the cross-subtype pages for questions that cut across subtypes.
3. Use support-group and project pages for downloads, pathways tools, practical resources, and community links.

***

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This information is for education only. It is not medical advice, diagnosis, or treatment. Please speak with a qualified clinician before making changes to care, medication, or supplement use.
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